Expression data from CH/LE Mice
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ABSTRACT: We are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs as well as SREBP-2 directly activates autophagy genes during cell sterol depletion, conditions known to induce both autophagy and nuclear SREBP-2 levels.
ORGANISM(S): Mus musculus
PROVIDER: GSE28083 | GEO | 2011/03/23
SECONDARY ACCESSION(S): PRJNA143127
REPOSITORIES: GEO
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