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Metformin Regulates Ferroptosis in Skin Cutaneous Melanoma

ABSTRACT: To explore the effects of metformin on the proliferation and ferroptosis of skin cutaneous melanoma (SKCM) and its potential molecular mechanisms, providing a new theoretical basis and strategy for the treatment of cutaneous melanoma. RNA-seq sequencing and related analyses were used to screen differentially expressed genes and explore their involved biological functions and signaling pathways. RNA-seq analysis found 2068 differentially expressed genes, of which 897 were up-regulated and 1171 were down-regulated. The related pathways such as iron metabolism disorders and ferroptosis were activated.

ORGANISM(S): Homo sapiens

PROVIDER: GSE280924 | GEO | 2024/12/27

REPOSITORIES: GEO

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Metformin Regulates Ferroptosis in Skin Cutaneous Melanoma

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