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Genetic perturbations direct the development of distinct brain tumor types from postnatal neural stem/progenitor cells

ABSTRACT: Primary brain tumors are classified and treated based on their histological features, however the factors which specify these tumor types remain largely unknown. We demonstrate that the over-expression of HRAS (V12) and MYC alone or in combination directs the development of glioma, CNS PNET, and atypical teratoid/rhabdoid (AT/RT)-like tumors from postnatal murine p53-deficient neural stem/progenitor cells. Microarray analyses were performed to investigate the gene expression profile of the tumor cells generated by the different genetic perturbations.

ORGANISM(S): Mus musculus

PROVIDER: GSE28095 | GEO | 2012/03/21

SECONDARY ACCESSION(S): PRJNA139785

REPOSITORIES: GEO

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Genetic perturbations direct the development of distinct brain tumor types from postnatal neural stem/progenitor cells

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