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The effect of Dinc defficiency on the mouse paneth cell transcriptome

ABSTRACT: We invstigated the effect of zinc depletion on the mouse intestine, and specifically on paneth cells. Mice ere placed on a zinc depleted diet for 7 weeks after which the the effects of dietary zinc shortage on paneth cells were investigated. A zinc is an essential element for correct paneth cell function and zinc defficiency is a human and animal health problem investigating the PC transcriptom my provide valuable insights into the exact mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE281801 | GEO | 2025/02/26

REPOSITORIES: GEO

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The effect of Zinc defficiency on the mouse paneth cell transcriptome in TNF context

Project description:We investigated the effect of zinc depletion on the mouse intestine, and specifically on paneth cells. Mice were placed on a zinc depleted diet for 7 weeks after which they were given TNF for 3 hours and the the effects of dietary zinc shortage on paneth cells in TNF context were investigated. A zinc is an essential element for correct paneth cell function and zinc defficiency is a human and animal health problem investigating the PC transcriptom my provide valuable insights into the exact mechanism.

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Paneth cells

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