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Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish

ABSTRACT: The often-prominent pigment patterns of vertebrates are varied in form and function and depend on several types of pigment cells derived from embryonic neural crest or latent stem cells of neural crest origin. These cells and the patterns they produce have been useful for uncovering features of differentiation and morphogenesis that underlie adult phenotypes, and they offer opportunities to discover how patterns and the cell types themselves have diversified. In zebrafish, a body pattern of stripes arises by self organizing interactions among three types of pigment cells. Yet these fish also exhibit white ornamentation on their fins that depends on the transdifferentiation of black melanophores to white cells, “melanoleucophores.” To identify mechanisms underlying this conversion we used ultrastrustructural, transcriptomic, mutational and other approaches.

ORGANISM(S): Danio rerio

PROVIDER: GSE282061 | GEO | 2025/01/30

REPOSITORIES: GEO

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Expression data from zebrafish pigment cells at adult stage

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