Transcriptomics

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A broad phenotypic screen identifies novel dominant phenotypes in Huntington’s disease CAG knock-in mice


ABSTRACT: Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder characterized by abnormal voluntary and involuntary movements, cognitive impairment and psychiatric disturbances. In order to identify phenotypic changes in the mouse that are most likely to be relevant to events triggered by the CAG repeat expansion in HD patients, we are interested in the earliest events that are triggered by expression of a single allele’s worth of full-length mutant huntingtin in the mouse, whether at the molecular, cellular or whole animal level. To this end, we have undertaken a broad-based, unbiased phenotypic screen in heterozygous HdhQ111/+ C57BL/6J mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE28232 | GEO | 2011/10/01

SECONDARY ACCESSION(S): PRJNA139601

REPOSITORIES: GEO

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