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H. pylori SlyD Enhances TPT1 Stability via hnRNPK to Promote OCT1-Mediated CDX2 Transcriptional Activation Triggering Gastric Intestinal Metaplasia

ABSTRACT: Gastric intestinal metaplasia (GIM) is an important precancerous lesion in intestinal-type gastric cancer, with persistent Helicobacter pylori (H. pylori) infection inducing the condition. In a previous study, we identified a new H. pylori virulence factor, SlyD. However, its mode of action between GIM was unknown. Our findings offer clues to reveal the molecular mechanism of H.pylori infection-associated gastric intestinal metaplasia, and provides the mechanism of a novel H. pylori virulence factor SlyD in gastric precancerous disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE282336 | GEO | 2024/11/26

REPOSITORIES: GEO

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