Menthol effect on gene expression profile in malignant prostate cancer cell lines, PC-3

ABSTRACT: Menthol, a naturally occurring cooling compound of peppermint oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that dysregulated cell cycle progression of PC-3 cells to menthol. We performed microarray experiments to obtain a global view of how menthol affects prostate cancer biology in gene expression profile. Our study demonstrated that menthol induced G2/M arrest by dysregulating PLK1 in the AICP cell model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28241 | GEO | 2011/08/31

SECONDARY ACCESSION(S): PRJNA139587

REPOSITORIES: GEO