Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment
Ontology highlight
ABSTRACT: We used single-cell RNA sequencing to investigate the differences in the transcriptional landscapes between stiff and compliant MMTV-PyMT mouse mammary tumors. We found similar compositions of cancer and stromal subpopulations in compliant and stiff tumors but differential intercellular communication and a significantly higher concentration of tumor-promoting, M2-like macrophages in the stiffer tumor microenvironments.
ORGANISM(S): Mus musculus
PROVIDER: GSE283034 | GEO | 2024/12/04
REPOSITORIES: GEO
ACCESS DATA