Transcriptomics

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ScRNAseq gene expression profile of zebrafish jaw joint cells after complete resection of the synovial jaw joint


ABSTRACT: Adult mammalian synovial joints have limited regenerative capacity, where injuries heal with mechanically inferior fibrotic joint tissues. Here we developed a unilateral whole-joint resection model in adult zebrafish to advance our understanding of how to stimulate regrowth of native synovial joint tissues. Using single-cell RNA sequencing, we profile RNA expression from live-sorted jaw joint cells throughout the time course of joint regeneration (1 to 70 days-post-joint-resection (dpjr)). Our findings reveal latent molecular and cellular programs within the adult skeleton that are deployed to regenerate a complex joint with lubricated articular cartilage.

ORGANISM(S): Danio rerio

PROVIDER: GSE283763 | GEO | 2024/12/16

REPOSITORIES: GEO

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