Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity
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ABSTRACT: Drug resistance and immune escape continue to contribute to poor prognosis in AML. Increasing evidence suggests that exosomes play a crucial role in AML immune microenvironment. We aimed to find a functional exosomal circRNAs/lncRNA/mRNA correlating with the progression of AML patients and further analyze its underlying mechanism in AML cells and tumor microenvironment immune cells. We find a new crucial exosomal circRNA, circ_0006896, is upregulated in both AML cells and exosomes and correlates with the prognosis and relapse of AML. In vitro and in vivo studies suggest that circ_0006896 significantly promotes AML cell proliferation, reduces chemotherapy sensitivity, and more importantly, impairs the efficacy of adoptive T cell-transfer immunotherapy.
ORGANISM(S): Homo sapiens
PROVIDER: GSE285301 | GEO | 2024/12/31
REPOSITORIES: GEO
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