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Anthrax Lethal Toxin-Inducd Gene Expression Changes in Mouse Lung

ABSTRACT: Enhanced susceptibility of A/J mice to death by systemic anthrax lethal toxin (LeTx) administration compared to the C57BL/6 strain was observed. In this study we investigated whether systemic exposure of mice to LeTx would induce gene expression changes associated with vascular/capillary leakage in lung tissue. Lungs of the less susceptible C57BL/6 strain showed 80% fewer differentially expressed genes compared to lungs of the more sensitive A/J strain.

ORGANISM(S): Mus musculus

PROVIDER: GSE28554 | GEO | 2011/09/07

SECONDARY ACCESSION(S): PRJNA139069

REPOSITORIES: GEO

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Anthrax Lethal Toxin-Inducd Gene Expression Changes in Mouse Lung

Project description:Enhanced susceptibility of A/J mice to death by systemic anthrax lethal toxin (LeTx) administration compared to the C57BL/6 strain was observed. In this study we investigated whether systemic exposure of mice to LeTx would induce gene expression changes associated with vascular/capillary leakage in lung tissue. Lungs of the less susceptible C57BL/6 strain showed 80% fewer differentially expressed genes compared to lungs of the more sensitive A/J strain. Total RNA obtained from lung tissue of C57Bl/6 and A/J strain mice exposed for 6 and 12 hrs to wild-type and mutant Bacillus anthracis.

2011-09-06 | E-GEOD-28554 | biostudies-arrayexpress

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