Transcriptomics

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8-miR cluster deletion affects mef2 levels in Drosophila melanogaster


ABSTRACT: Loss of nautilus (MyoD) gene function results in a variable phenotype affecting muscle formation in embryos and larvae, larval movement, pupal eclosion, egg deposition, adult mobility and survival. 8-miR cluster deletion disrupts muscle formation in the embryo while affecting protein production from the nautilus, dMef2 , regulators of the muscle transcriptional network. We propose the complex phenotype in the nautilus null is due to the disruption of the regulatory interactions provided by the 8-miR cluster. The results demonstrate that nautilus is an integral regulator of the miRNA circuitry buffering the transcriptional network directing muscle development.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE28604 | GEO | 2015/04/01

SECONDARY ACCESSION(S): PRJNA143007

REPOSITORIES: GEO

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