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Progastrin dependent cancer cell proliferation

ABSTRACT: Overexpression of human progastrin (hGAS) in mice has been observed to increase colonic mucosa proliferation significantly, but the mechanism and receptors of progastrin have not been defined. We investigated this mechanism by observing the microarray gene expression in mGAS-/- mice, WT mice, and hGAS transgenic mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE28620 | GEO | 2016/04/03

SECONDARY ACCESSION(S): PRJNA138741

REPOSITORIES: GEO

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Progastrin dependent cancer cell proliferation

Project description:Overexpression of human progastrin (hGAS) in mice has been observed to increase colonic mucosa proliferation significantly, but the mechanism and receptors of progastrin have not been defined. We investigated this mechanism by observing the microarray gene expression in mGAS-/- mice, WT mice, and hGAS transgenic mice. Gene expression of colonic mucosa of WT C57BL/6 mice,Gas-/- C57BL/6 mice, and hGAS transgenic mice, all 6 weeks old were compared.

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