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Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma

ABSTRACT: We here applied single-cell RNA sequencing of circulating T-cells from primary MM patients to perform transcriptional profiling and assess T-cell fitness in the context of emerging resistance to CAR-T cell therapy. Response to PD-1 inhibition after CAR-T was dictated by the fitness state of non-CAR T cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE286237 | GEO | 2025/02/01

REPOSITORIES: GEO

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