Transcriptomics

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Differential gene expression in uterosacral ligament from patients with recurrent and primary pelvic organ prolapse


ABSTRACT: Objective: The objective of this study was to profile differential gene expression in three distinct patient groups. Study Design: The groups consisted of women with recurrent POP, women with primary POP and women without POP. Whole human genome DNA microarrays were used to evaluate differential gene expression in uterosacral ligament (USL) tissues. Results: 10 genes of interest were identified in USL. Eight genes were over expressed 30-fold or greater, and two genes were under expressed. Confirmation of differential gene expression used the technique of real-time RT-PCR. Five of the substantially over expressed genes functioned in the distribution, metabolism or deposition of adipose tissue. Homeobox genes D10 and D11 were under expressed. Conclusions: The differential gene expression seen in the USL tissues in women with recurrent POP suggests that USLs are weakened by changes directed by these genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28660 | GEO | 2019/03/27

REPOSITORIES: GEO

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