Genomics

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Genome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle


ABSTRACT: We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes at the OX growth phase of the yeast metabolic cycle indicating acetyl-CoA levels may drive growth gene transcription program through acetylation of these proteins.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE28734 | GEO | 2011/05/19

SECONDARY ACCESSION(S): PRJNA140547

REPOSITORIES: GEO

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