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Conditional deletion of Bcl6 in naive B cells

ABSTRACT: Bcl6 germline deletion causes a prominent inflammatory disease, owing to over-expression of Th2 cytokines, and affects the properties of B cells prior to immunization. Therefore we established the B cell-specific Bcl6 deletion mice and analyze the gene expression of naive B cells under physiological conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE28737 | GEO | 2012/09/21

SECONDARY ACCESSION(S): PRJNA140553

REPOSITORIES: GEO

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Conditional deletion of Bcl6 in naive B cells

Project description:Bcl6 germline deletion causes a prominent inflammatory disease, owing to over-expression of Th2 cytokines, and affects the properties of B cells prior to immunization. Therefore we established the B cell-specific Bcl6 deletion mice and analyze the gene expression of naive B cells under physiological conditions. Total RNAs of splenic follicular and marginal zone B cells from Bcl6(flox/flox), Bcl6(+/flox) or Bcl6(+/+) mice heterozygous for mb1-cre were extracted and analysed on Affymetrix microarrays.

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