Transcriptomics

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Expression changes in the XY fetal gonads due to iron deficiency


ABSTRACT: Iron plays an important role in epigenome regulation by acting as a cofactor.We developed a method to enrich pre-Sertoli (Nr5a1 positive(+)) cells from mouse embryonic gonads carrying Nr5a1-hCD271 transgene. To examine mRNA expression in pre-Sertoli cells treated with the iron chelator Deferoxamine (Dfo), pre-Sertoli cells were purified and introduced into RNA seq analyses. As a result, we found that the expression of many genes, including Sry, changes due to iron deficiency.

ORGANISM(S): Mus musculus

PROVIDER: GSE287387 | GEO | 2025/02/05

REPOSITORIES: GEO

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