Single-cell transcriptomics revealed e-cigarettes-induced vascular remodeling by enhancing Tcf21 expression
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ABSTRACT: Electronic cigarettes (e-cigs) are battery-powered new tobacco products attracting wide attention due to their potential in promoting smoking cessation and uncertainty in long-term health effects. According to the scientific statement from the American Heart Association (AHA), e-cig use may be a potential threat to the cardiopulmonary system and populational studies suggested that e-cig aerosol could enhance arterial stiffness Laboratory evidence suggested that e-cigs could accelerate atherosclerosis and atherosclerosis or aortic aneurysm in mice, while the exact mechanisms of e-cig-related vascular effects remained largely unknown. Here, we investigate the sub-chronic effects of e-cig aerosol on vascular structure, function, and changes in single-cell transcriptome in mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE288003 | GEO | 2025/01/31
REPOSITORIES: GEO
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