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Gene expression patterns in response to GATA2 (WT and mutants) in HL-60 cells

ABSTRACT: GATA2 mutants were discovered in families predisposed to MDS/AML and in sporadic cases of CML-blast crisis. Promyelocytic HL-60 cells were transduced with lentiviral vectors that express GATA2 WT or T354M, 355delT or L359V mutants upon addition of 4-hydroxy tamoxifen (4HT). Microarrays were performed to identify GATA2 WT signatures and differences caused by these mutations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE29276 | GEO | 2011/08/20

SECONDARY ACCESSION(S): PRJNA139931

REPOSITORIES: GEO

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Gene expression patterns in response to GATA2 (WT and mutants) in HL-60 cells

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