Transcriptomics

Dataset Information

0

Streptococcus gallolyticus modulates phase I biotransformation enzymes in colorectal cancer cells through the aryl hydrocarbon receptor.


ABSTRACT: The opportunistic pathogen Streptococcus gallolyticus is one of the few intestinal bacteria that has been consistently linked to colorectal cancer (CRC). This study aimed to identify S. gallolyticus-induced pathways that could on the long-term add to CRC progression. Transcription profiling of S. gallolyticus-exposed CRC-cells revealed the persistent induction of enzymes involved in biotransformation pathways. Specifically, a diffusible factor of S. gallolyticus (SGF-X) interacts with the aryl hydrocarbon receptor thereby inducing CYP1 enzymes that catalyze the bioactivation of polycyclic aromatic hydrocarbons (PAHs) into toxic intermediates. Importantly, priming CRC-cells with SGF-X containing medium increased the DNA damaging effect of the PAH 3-methylcholanthrene, which was not observed for other intestinal bacteria. In conclusion, this study shows for the first time that bacteria can modulate the biotransformation capacity of CRC-cells that offers a novel theory for a contributing role of S. gallolyticus in the etiology of sporadic CRC. Key words : Colorectal cancer cells, Streptococcus bovis, streptococcus gallolyticus, host-pathogen interactions, Cytochrome P4501A1, DNA-damage, polycyclic aromatic hydrocarbons

ORGANISM(S): Homo sapiens

PROVIDER: GSE29295 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA138619

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-12-31 | E-TABM-353 | biostudies-arrayexpress
2020-10-28 | GSE156147 | GEO
2009-05-21 | GSE14207 | GEO
2008-12-11 | E-MEXP-1685 | biostudies-arrayexpress
| PRJNA656884 | ENA
| PRJNA744876 | ENA
2016-06-06 | GSE82242 | GEO
2022-07-08 | GSE134069 | GEO
2010-05-18 | E-GEOD-14207 | biostudies-arrayexpress
| PRJNA590550 | ENA