Transcriptomics

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Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma [pituitary]


ABSTRACT: As overwhelming evidence coming from transgenic mouse models but also from MEN4 patients seem to suggest that loss or inactivation of a single p27 allele plays an important role in neuroendocrine tumorigenesis, we decided to perform a detailed analysis of the phenotype of rats heterozygous for the MENX-associated germline Cdkn1b mutation. We here show that the reduction to a single functional p27 allele predisposes MENX heterozygous rats to the development of neuroendocrine malignancies.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE29457 | GEO | 2017/11/15

SECONDARY ACCESSION(S): PRJNA141575

REPOSITORIES: GEO

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