Combinatorial effects of microRNA to suppress the myc oncogenic pathway (mRNA data)
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ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE29492 | GEO | 2012/04/09
SECONDARY ACCESSION(S): PRJNA153981
REPOSITORIES: GEO
Similar Datasets
Project description:microRNA importance in the myc pathway in Burkitt lymphoma.
2012-04-09 | GSE29491 | GEO
Project description:microRNA importance in the myc pathway in Burkitt lymphoma. Gene expression data of Burkitt lymphoma samples and non-tumoral controls. 6 Burkitt lymphomas were compared with 16 non-tumoral controls. Universal Human Reference RNA was used as the reference sample. Significantly deregulated miRNAs were computed using the Significant Analysis of Microarray (SAM) analysis from the TM4 pathway and the limma package.
2012-04-08 | E-GEOD-29492 | biostudies-arrayexpress
Project description:microRNA importance in the myc pathway in Burkitt lymphoma. MicroRNA data from the Agilent human miRNA platform. 12 Burkitt lymphomas were compared with 14 non-tumoral controls (lymph nodes, tonsils and CD19+CD10+ sorted cells). Significantly deregulated miRNAs were computed using the Significant Analysis of Microarray (SAM) analysis from the TM4 pathway and the limma package.
2012-04-08 | E-GEOD-29491 | biostudies-arrayexpress
Project description:Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, one of the hallmark oncogenes in these lymphomas, stands out as the up-regulated gene with the highest number of genetic interactions with down-regulated miRNAs in mouse lymphomas. The regulation of Myc by several of these miRNAs is confirmed by cellular and reporter assays. The same approach identifies MYC and multiple Myc targets as a preferential target of down-regulated miRNAs in human Burkitt lymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that several miRNAs must be coordinately down-regulated to enhance critical oncogenes, such as Myc. Some of these Myc-targeting miRNAs are repressed by Myc, suggesting that these tumors are a consequence of the unbalanced activity of Myc versus miRNAs. This SuperSeries is composed of the following subset Series: GSE29491: Combinatorial effects of microRNA to suppress the myc oncogenic pathway (miRNA data) GSE29492: Combinatorial effects of microRNA to suppress the myc oncogenic pathway (mRNA data)
2012-03-29 | E-GEOD-23026 | biostudies-arrayexpress
Project description:Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, one of the hallmark oncogenes in these lymphomas, stands out as the up-regulated gene with the highest number of genetic interactions with down-regulated miRNAs in mouse lymphomas. The regulation of Myc by several of these miRNAs is confirmed by cellular and reporter assays. The same approach identifies MYC and multiple Myc targets as a preferential target of down-regulated miRNAs in human Burkitt lymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that several miRNAs must be coordinately down-regulated to enhance critical oncogenes, such as Myc. Some of these Myc-targeting miRNAs are repressed by Myc, suggesting that these tumors are a consequence of the unbalanced activity of Myc versus miRNAs. This SuperSeries is composed of the SubSeries listed below.
2012-03-30 | GSE23026 | GEO
Project description:Identification of miRNA differentially expressed between MYC-translocation positive and and MYC-translocation negative Burkitt Lymphoma and their impact on gene expression profile Study of microRNA profile of MYC-translocation positive and MYC-translocation negative Burkitt Lymphoma cases in order to uncover possible differences at the molecular level
2015-08-05 | E-GEOD-71471 | biostudies-arrayexpress
Project description:c-myc-3'RR mice prone to develop Burkitt lymphoma (BL) were crossed with p53+/- mice in order to obtain c-myc-3'RR/p53+/- mice. These mice develop a wider spectrum of lymphoma including BL, mantle cell lymphoma (MCL) and plasma cell lymphoma (PCL). Transcriptoma analysis of these lymphomas is investigated in these arrays. Four different plasma cell lymphoma (PCL1-4), three different mantle cell lymphoma (MCL1-4) and four different Burkitt lymphoma (BL1-4) were compared.
2012-01-05 | E-GEOD-31814 | biostudies-arrayexpress
Project description:Identification of miRNA differentially expressed between MYC-translocation positive and and MYC-translocation negative Burkitt Lymphoma and their impact on gene expression profile
2015-08-05 | GSE71471 | GEO
Project description:Abstract. Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematological malignancies enhanced NF-kB exerts prosurvival functions. Here we investigated the role of NF-kB in mouse and human c-MYC-transformed lymphomas. The NF-kB-pathway is extinguished in murine lymphoma cells and extrinsic stimuli typically inducing NF-kB activity fail to activate this pathway. Genetic activation of the NF-kB pathway induces apoptosis in these cells, while inhibition of NF-kB by an IkBa superrepressor provides a selective advantage in vivo. Furthermore, in human Burkitt´s lymphoma cells we find that NF-kB activation induces apoptosis. NF-kB upregulates Fas and predisposes to Fas-induced cell death, which is caspase 8 mediated and can be prevented by CFLAR overexpression. We conclude that c-MYC overexpression sensitizes cells to NF-kB-induced apoptosis and persistent inacvtivity of NF-kB signaling is a prerequisite for MYC-mediated tumorigenesis. We could also show that low immunogenicity and Fas insensitivity of MYC driven lymphoma cells is reversed by activation of NF-kB. Our observations provide a molecular explanation for the described absence of the NF-kB signaling in Burkitt´s lymphoma and question the applicability of NF-kB inhibitors as candidates for treatment of this cancer.
2009-07-22 | GSE17129 | GEO
Project description:c-myc-3'RR mice prone to develop Burkitt lymphoma (BL) were crossed with p53+/- mice in order to obtain c-myc-3'RR/p53+/- mice. These mice develop a wider spectrum of lymphoma including BL, mantle cell lymphoma (MCL) and plasma cell lymphoma (PCL). Transcriptoma analysis of these lymphomas is investigated in these arrays.
2012-01-05 | GSE31814 | GEO