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Hippocampal epitranscriptomic (m6A) in IA-KA mouse model of Temporal Lobe Epilepsy

ABSTRACT: RNA is subject to extensive processing and modification. N6-methyladenosine (m6A) is the most abundant internal modification and regulates RNA fate in several ways including stability and translational efficiency. Here, we provide a detailed analysis of the m6A-ome in hippocampus of a mouse model of temporal lobe epilepsy during epileptogenesis and into the epilepsy stage of the disease. Our results suggest that m6A represents a novel layer of complexity in gene regulation in epilepsy.

ORGANISM(S): Mus musculus

PROVIDER: GSE295244 | GEO | 2025/04/22

REPOSITORIES: GEO

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