MRNA and microRNA profile in colon cancer [mRNA data]
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE29621 | GEO | 2014/01/01
SECONDARY ACCESSION(S): PRJNA153829
REPOSITORIES: GEO
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Project description:Compariosn of mRNA and miRNA profile in colon cancer mRNA was extracted from colon tissues for microarray analysis
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Project description:Sprouty proteins are evolutionarily conserved modulators of mitogen-activated protein kinase pathway. Sprouty2 appears to function as a tumor suppressor in cancers, whereas we reported earlier that Sprouty2 functions as an oncogene in colorectal cancer. To further understand the oncogenic potential of Sprouty2 in the colon, microRNA expression profile of colon cancer cells was investigated. Sprouty2 suppression in HCT116 colon cancer cells significantly increased MicroRNA 194-5p. Sprouty2 dependent regulation of microRNA194-5p and its biological targets were studied further for their tumor suppressive actions in reducing epithelial-mesenchymal transition in colorectal cancer.
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2021-04-06 | PXD021722 |