Transcriptomics

Dataset Information

0

Tuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function


ABSTRACT: The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescent program in naïve T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-deficient T cells to apoptosis that depleted conventional T cells and invariant natural killer T cells. Loss of Tsc1 function dampened in vivo immune responses to bacterial infection. Tsc1-deficient T cells exhibited increased mTORC1 but diminished mTORC2 activities, with mTORC1 activation essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in establishing naïve T cell quiescence to facilitate adaptive immune function.

ORGANISM(S): Mus musculus

PROVIDER: GSE29797 | GEO | 2011/07/12

SECONDARY ACCESSION(S): PRJNA141013

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-07-11 | E-GEOD-29797 | biostudies-arrayexpress
2020-11-23 | PXD020734 | Pride
2014-09-20 | E-GEOD-61591 | biostudies-arrayexpress
2018-10-24 | PXD002670 | Pride
2020-08-11 | PXD014832 | Pride
2014-09-20 | GSE61591 | GEO
2021-05-28 | GSE175620 | GEO
2021-07-22 | GSE180173 | GEO
2023-10-27 | GSE239412 | GEO
2010-07-30 | E-GEOD-21755 | biostudies-arrayexpress