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Cisplatin-induced gene expression in DNA adenine methyltransferase (dam) and mismatch repair deficient E. coli

ABSTRACT: We used Affymetrix microarrays to determine the cisplatin-induced gene expression changes in E. coli deficient in dam and mismatch repair (dam, dam mutS, and mutS mutant strains). E. coli deficient in dam are hypersensitive to cisplatin. However introducing an additional mutation in mismatch repair (i.e., a mutation in mutS or mutL) abrogates this sensitivity and essentially restores wildtype levels of resistance. Keywords: Drug-induced expression

ORGANISM(S): Escherichia coli K-12 Escherichia coli

PROVIDER: GSE2999 | GEO | 2005/07/27

SECONDARY ACCESSION(S): PRJNA91913

REPOSITORIES: GEO

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Transcription profiling of E. coli dam and mutS mutants exposed to cisplatin

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Escherichia coli

Project description:Cisplatin-induced gene expression in DNA adenine methyltransferase (dam) and mismatch repair deficient E. coli

| PRJNA91913 | ENA

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Project description:Basal gene expression in dam, dam mutS, and mutS mutant E. coli strains

| PRJNA92623 | ENA