Transcriptomics

Dataset Information

0

Expression data from human mesenchymal stem cell and osteosarcoma cells


ABSTRACT: To determine whether enhanced self-renewal and tumorigenicity in UT2 cells (derived from the second human–mouse xenotransplantation of U2OS cell-formed osteosarcoma tissues) correlate with increased expression of stem/progenitor cell-associated genes, we measured global gene expression in MSC, U2OS and UT2 cells by microarray analysis. Compared to U2OS and MSC, molecules involved in regulation of self-renewal signaling pathways of cancer stem cells were also up-regulated in UT2 cells, including those in the Notch, Wnt, and TGF-beta pathways. These data suggest a genetic basis for the enhanced self-renewal and tumorigenicity of osteosarcoma-initiating cell in UT2 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30807 | GEO | 2012/12/30

SECONDARY ACCESSION(S): PRJNA144209

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-12-30 | E-GEOD-30807 | biostudies-arrayexpress
2012-03-02 | GSE27900 | GEO
2012-03-02 | E-GEOD-35576 | biostudies-arrayexpress
2023-12-31 | GSE171671 | GEO
2021-09-08 | PXD013987 | Pride
2023-10-16 | GSE192547 | GEO
2017-04-12 | GSE96964 | GEO
2012-03-02 | E-GEOD-27900 | biostudies-arrayexpress
2014-05-22 | E-GEOD-57884 | biostudies-arrayexpress
2017-06-13 | GSE94126 | GEO