Transcriptomics

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Genome-wide mRNA expression profiles of FACS-purified rat beta cells freshly isolated from control and 24h-fasted rats


ABSTRACT: The study was designed to capture the in vivo adaptations of nutrient-sensing pancreatic beta cells to fed or fasted (24h) state. Short periods of fasting are thought to mediate the beta cells’ competence for insulin synthesis and secretion. We examined whether it influenced their typical mRNA expression. After 24h of fasting, a 1.5 fold change was detected in 1.5% of all assayed transcripts (p<0.05), with 95% of altered genes (430 of 452) being down-regulated (Fig.6A). Suppression was more marked for a panel of genes with beta cell-specific expression, of which 12% were 1.5-fold suppressed. Suppressed beta cell marker genes were statistically enriched in gene clusters of endoplasmic reticulum (ER), ER to Golgi transport, protein folding and secretory vesicle-mediated transport, i.e. the pathways of protein synthesis and transport. (See Martens G.A. et al. PLoS One 2011)

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE30964 | GEO | 2011/09/01

SECONDARY ACCESSION(S): PRJNA146225

REPOSITORIES: GEO

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