Transcriptomics

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Gene expression profile of human epidermoid carcinoma KB cells that overexpress thymidine phosphorylase


ABSTRACT: Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, deoxyuridine, and their analogs to the respective bases and 2-deoxy-D-ribose-1-phosphate. TP is identical to platelet-derived endothelial cell growth factor (PD-ECGF). TP was reported to induce many angiogenic factors. However, the molecular mechanism of the TP function is still obscure. To elucidate the molecular basis for the TP function in human epidermoid carcinoma KB cells, we performed a whole genome-wide microarray analysis. Genes upregulated in KB cells overexpressing TP are supposed to represent potential molecular targets of TP in KB cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE31467 | GEO | 2014/08/03

SECONDARY ACCESSION(S): PRJNA145665

REPOSITORIES: GEO

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