Transcriptomics

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Mechanism of lacritin-dependent production of the important dry eye mucin 'MUC16'


ABSTRACT: Lacritin targets its coreceptor 'syndecan-1' in lacritin-dependent production of the important dry eye mucin 'MUC16'. Real-time PCR analysis suggests that this effect is post-transcriptional. In contrast, serum stimulation of MUC16 by these cells is transcriptionally dependent. Our goal is to determine whether this regulation is global to other heavily O-glycosylated proteins, and if so, if it is dependent on transcription of a Golgi glycosyltransferases. If not, the mechanism might be microRNA dependent.

ORGANISM(S): Homo sapiens

PROVIDER: GSE31930 | GEO | 2011/09/06

SECONDARY ACCESSION(S): PRJNA145025

REPOSITORIES: GEO

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