Transcriptomics

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Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay


ABSTRACT: We apply a massively parallel reporter assay (MPRA) that relies on mRNA and plasmid tag sequencing (Tag-Seq) to compare the regulatory activities of more than 27,000 distinct variants of two inducible enhancers in human cells: a synthetic cAMP-regulated enhancer and the virus-inducible interferon beta enhancer. The resulting data define accurate maps of functional transcription factor binding sites in both enhancers at single-nucleotide resolution and can be used the to train quantitative sequence-activity models (QSAMs).

ORGANISM(S): Escherichia coli Homo sapiens

PROVIDER: GSE31982 | GEO | 2012/02/26

SECONDARY ACCESSION(S): PRJNA145181

REPOSITORIES: GEO

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