Expression data from granulocytic MDSC cultured with T cells in the absence of IFNgamma
Ontology highlight
ABSTRACT: Myeloid derived Suppressor cells (MDSC) are heterogenous popluation of cells consists of two major subsets namely the monocytic Gr-1dull/int. and granulocytic (Gr-1high). These distinct two subsets use different mechanism to inhibit T cell response. In addition, how the function of these subsets is regulated is not known yet. The Gr-1dull/int. MDSC are suppressing T cells through IFNg dependent nitric oxide dependent manner. However, the exact suppressive mechanism of Gr-1high MDSC is not clear. Here we studied the role of a cytokine IFNg on the suppressive function of Gr-1high MDSC by comparing the gene expression of Gr-1high cells cultured alone versus those cultured with T cells which donot produce IFNgamma.
ORGANISM(S): Mus musculus
PROVIDER: GSE32000 | GEO | 2011/09/09
SECONDARY ACCESSION(S): PRJNA145153
REPOSITORIES: GEO
ACCESS DATA