Regulation of gene expression by GLIPR1 in prostate cancer cells
Ontology highlight
ABSTRACT: Human glioma pathogenesis-related protein 1 (GLIPR1) and its mouse counterpart, Glipr1 are downregulated in prostate cancer (PCa) and other malignant cell lines, owing partly to methylation in the gene’s regulatory region. Loss of Glipr1 function predisposed mice to tumorigenesis. Restoration of GLIPR1 expression in prostate cancer cells and other malignant cells led to growth suppression and/or apoptosis. Here we show that restoring GLIPR1 expression in PCa cells leads to downregulated c-myc and cell cycle-related c-myc target genes, leading to the inhibition of cell cycle progression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE32367 | GEO | 2011/09/26
SECONDARY ACCESSION(S): PRJNA147693
REPOSITORIES: GEO
ACCESS DATA