Two types of estrogen receptor-positive (ER+) and -negative (ER-) breast cancer will be compared with glycan structure analyses
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ABSTRACT: ER+ve and ER-ve breast cancers tend to show different patterns of metastasis, with ER+ve tumours having a propensity to metastasize to the bone while ER-ve tumours tend to induce visceral metastasis. Glycans can play an important role in metastasis through their interactions with glycan binding proteins. Moreover we, and others have also shown that expression of particular tumor-associated glycoforms of the mucin MUC1, allows it to interact with lectins of the immune system. We now have data showing differences in the level of expression of some glycosyltransferases in ER+ve and ER-ve of breast cancer suggesting the expression of different O-linked glycoforms.
ORGANISM(S): Homo sapiens
PROVIDER: GSE32394 | GEO | 2011/09/26
SECONDARY ACCESSION(S): PRJNA147945
REPOSITORIES: GEO
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