Transcriptomics

Dataset Information

0

Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease


ABSTRACT: The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. This was associated with lower fatty acid synthesis and reduced SREBP-c signaling in the 5% corn oil group. Overfeeding 70% fat diets increased steatosis and lead to increased liver necrosis in the 70% corn oil but not olive oil group. Increased injury after feeding polyunsaturated fat diets was linked to peroxidizability of hepatic free fatty acids and triglycerides and appearance of peroxidaized lipid products HETES and HODES previously linked to clinical nonalcoholic steatohepatitis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE33166 | GEO | 2011/10/24

SECONDARY ACCESSION(S): PRJNA149237

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-10-23 | E-GEOD-33166 | biostudies-arrayexpress
2008-06-20 | E-GEOD-8253 | biostudies-arrayexpress
2008-05-19 | GSE8253 | GEO
2016-07-03 | E-GEOD-40654 | biostudies-arrayexpress
2016-01-01 | GSE40654 | GEO
2008-10-21 | E-GEOD-12028 | biostudies-arrayexpress
2023-12-21 | GSE232133 | GEO
2012-06-17 | E-GEOD-18586 | biostudies-arrayexpress
2007-10-10 | E-GEOD-3512 | biostudies-arrayexpress
2016-08-31 | GSE76622 | GEO