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Gene expression analysis of human iPSC generated from pathogenic LRRK2 (G2019S) mutation bearing patients

ABSTRACT: Genetic mutations on leucine-rich repeat kinase 2 (LRRK2) have been associated with an increased risk of Parkinson's disease. The Gly2019Ser (G2019S) mutation on LRRK2 gene is a relatively common cause of familial Parkinson's disease in Caucasian population. In this study, we generated human induced pluripotent stem cell (iPSC) lines from LRRK2 (G2019S) bearing patient fibroblasts by cell reprogramming. We performed global gene expression profiling of LRRK2 (G2019S) heterozygous and homozygous patient iPSC lines, and the corresponding fibroblast lines they originated from. An age-matched wildtype human fibroblast line and H1 human embryonic stem cell (ESC) line were used as controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33298 | GEO | 2012/10/17

SECONDARY ACCESSION(S): PRJNA149275

REPOSITORIES: GEO

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Gene expression analysis of human iPSC generated from pathogenic LRRK2 (G2019S) mutation bearing patients

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