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Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Candida albicans Candida parapsilosis

PROVIDER: GSE33490 | GEO | 2011/11/05

SECONDARY ACCESSION(S): PRJNA148739

REPOSITORIES: GEO

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Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans.

Project description:Candida parapsilosis is a pathogenic fungus that is major cause of hospital-acquired infection, predominantly due to growth as biofilms on indwelling medical devices. It is related to Candida albicans, which remains the most common cause of candidiasis disease in humans. The transcription factor Bcr1 is an important regulator of biofilm formation in vitro in both C. parapsilosis and C. albicans. We show here that C. parapsilosis Bcr1 is required for in vivo biofilm development in a rat catheter model, like C. albicans. By comparing the transcription profiles of a bcr1 deletion in both species we found that regulation of expression of the CFEM family is conserved. In C. albicans, three of the five CFEM cell wall proteins (Rbt5, Pga7 and Csa1) are associated with both biofilm formation and acquisition of iron from heme, which is an important virulence characteristic. In C. parapsilosis, the CFEM family has undergone an expansion to 7 members. Expression of three genes (CFEM2, CFEM3, and CFEM6) is dependent on Bcr1, and is induced in low iron conditions. All three are involved in the acquisition of iron from heme. However, deletion of the three CFEM genes has no effect on biofilm formation in C. parapsilosis. Our data suggest that the role of the CFEM family in iron acquisition is conserved between C. albicans and C. parapsilosis, but their role in biofilm formation is not.

| S-EPMC3228736 | biostudies-literature

Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans

Project description:This SuperSeries is composed of the following subset Series: GSE33460: Transcriptional profile of Candida albicans bcr1 knockout. GSE33461: Transcriptional profile of Candida parapsilosis bcr1 knockout. GSE33462: Transcriptional profile of Candida parapsilosis CLIB214 culture in low iron conditions Refer to individual Series

2011-11-05 | E-GEOD-33490 | biostudies-arrayexpress

Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans

Project description:Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans

| PRJNA148739 | ENA

Hypoxia and biofilms in Candida parapsilosis