Transcriptomics

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Hepatic gene expression profiles after long-term high-fat diet feeding in wild type and Nrf2 knock-out mice.


ABSTRACT: To assess the role of the transcription factor NFE2 related factor 2 like 2 ( Nrf2) in the development of high-fat diet (HFD)-induced obesity and non-alcoholic HFD-induced fatty liver disease, 8 wild type (WT) and 8 Nrf2 knock-out (Nrf2-KO) C57BL6J male mice (obtained from Riken BRC, Tsukuba, Japan and originally developed by Prof. M. Yamamoto) were fed an HFD (60 kcal % fat) for 180 days. Whole genome microarray expression profiling was performed in pooled liver samples of WT and Nrf2-KO mice to identify genes that are differentially expressed between WT and Nrf2-KO mice under the stress conditions of HFD-induced obesity.

ORGANISM(S): Mus musculus

PROVIDER: GSE33575 | GEO | 2011/11/30

SECONDARY ACCESSION(S): PRJNA148571

REPOSITORIES: GEO

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