Identification of Proteins Binding Coding and Non-coding Human RNAs using Protein Microarrays
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ABSTRACT: We describe a refined approach to identify new human RNA-protein interactions. In vitro transcribed labeled RNA is bound to ~9,400 human recombinant proteins spotted on protein microarrays. This approach identified 137 RNA-protein interactions for 10 human coding and non-coding RNAs, including an interaction between Staufen 1 protein and TP53 mRNA that promoted the latter’s stability. RNA hybridization to protein microarrays allows rapid identification of human RNA-protein interactions on a large scale.
ORGANISM(S): Homo sapiens
PROVIDER: GSE34794 | GEO | 2012/10/10
SECONDARY ACCESSION(S): PRJNA151039
REPOSITORIES: GEO
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