Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile of Candida albicans in response to murine IL17A

ABSTRACT: Global transcriptional profiling revealed that IL-17A induced artificial nutrient starvation conditions in Candida albicans, resulting in a downregulated target of rapamycin (TOR) signaling pathway and in increased autophagic responses and intracellular cAMP.

ORGANISM(S): Candida albicans

PROVIDER: GSE35153 | GEO | 2012/01/18

SECONDARY ACCESSION(S): PRJNA150775

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profile of Candida albicans in response to murine IL17A

Project description:Global transcriptional profiling revealed that IL-17A induced artificial nutrient starvation conditions in Candida albicans, resulting in a downregulated target of rapamycin (TOR) signaling pathway and in increased autophagic responses and intracellular cAMP. We used microarray to detail the global programme of gene expression underlying IL17A sensing by Candida albicans at different time points (T0_0h T1_4h, T2_24h) and identified distinct classes of up-regulated and down regulated genes.

2012-01-18 | E-GEOD-35153 | biostudies-arrayexpress

The protein kinase Tor1 regulates adhesin expression in Candida albicans

Project description:Eukaryotic cell growth is coordinated in response to nutrient availability, growth factors, and environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin-sensitive Tor1 protein kinase, which is conserved from yeasts to humans, participates in a signaling pathway central to cellular nutrient responses. To gain insight into Tor-mediated processes in human fungal pathogens, we have characterized Tor signaling in Candida albicans. Global transcriptional profiling revealed evolutionarily conserved roles for Tor1 in regulating the expression of genes involved in nitrogen starvation responses and ribosome biogenesis. Interestingly, we found that in C. albicans Tor1 plays a novel role in regulating the expression of several cell wall and hyphal specific genes, including adhesins and their transcriptional repressors Nrg1 and Tup1. In accord with this transcriptional profile, rapamycin induced extensive cellular aggregation in an adhesin-dependent fashion. Moreover, adhesin gene induction and cellular aggregation of rapamycin-treated cells were strongly dependent on the transactivators Bcr1 and Efg1. These findings support models in which Tor1 negatively controls cellular adhesion by governing the activities of Bcr1 and Efg1. Taken together, these results provide evidence that Tor1-mediated cellular adhesion might be broadly conserved among eukaryotic organisms.

2009-02-21 | GSE13176 | GEO

Effects of inhibiting sphingolipid synthesis and TOR signaling on the Candida albicans transcriptome

Project description:Goal: We employed RNA-seq to detect changes in the transcriptome of the yeast Candida albicans in response to the addition of myriocin, a sphingolipid synthesis inhibitor, or caffeine, a drug that blocks the TOR kinase. The effects of the drugs were studied in wild-type cells and in the rtg3 mutant strain.

2019-04-01 | GSE125332 | GEO

Candida albicans

Project description:Candida albicans

| PRJNA308106 | ENA

Gene profile of mid-log phase of SD medium grown Candida albicans rhb1 gene deletion strain

Project description:Candida albicans is an opportunistic pathogenic yeast that is commensally found in variety of host niches. Rhb1 serves as an positive regulator of Tor1 kinase which is the central component of the TOR signaling in controlling several virulence factors. Here, we used microarray to determined changes in transcript profile while the cell lacks the RHB1 gene.

2012-03-15 | GSE29128 | GEO

Candida albicans

Project description:Candida albicans Sequencing

| PRJNA327830 | ENA

Comparative genomic hybridization of Candida albicans and Candida dublinienis

Project description:Comparative genomic hybridisation between Candida albicans and Candida dublinienis using Eurogentec Candida albicans whole genome microarrays

2004-04-30 | E-MEXP-99 | biostudies-arrayexpress

Candida albicans

Project description:Candida albicans Genome sequencing

| PRJNA265881 | ENA

Candida albicans

Project description:Candida albicans D-tagatose

| PRJNA634197 | ENA

Candida albicans

Project description:Candida albicans Genome sequencing

| PRJNA194436 | ENA