Transcriptomics

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Transcription profile of adipose derived mesenchymal stem cells separated by cell surface protein N-cadherin.


ABSTRACT: Mesenchymal stem cells (MSCs) are one of most promising stem cell sources for regenerative medicine. MSCs have a differention ability into several tissues. However, their differentiation efficiency is considered quite limited. Especially, the differentiation efficiency into cardiomyocytes is very low. N-cadherin is one of the cell surface protein that is expressed in developing and adult cardiomyocytes. We found that cell surface expression of N-cadherin in MSCs shows good correlation with the cardiomyogenic differentiation ability. We also analyzed the expression profiles of N-cadherin-positive and N-cadherin-negative fraction by microarray. We found that N-cadherin-positive MSCs show higher expression of some of the cardiomyogenesis-related genes than N-cadherin-negative MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE35232 | GEO | 2013/10/29

SECONDARY ACCESSION(S): PRJNA152859

REPOSITORIES: GEO

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