Transcriptomics

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Transcriptional profiles of transgenic ALK^F1174L/MYCN vs. MYCN tumors


ABSTRACT: The ALK^F1174L mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK^F1174L in the neural crest. Comapred to mice expressing ALK^F1174L or MYCN alone, combined expression of the two aberrations led to development of neuroblastoma with a shorter latency and higher penetrance. Here, we evaluated the transcriptional profiles of MYCN-driven neuroblastomas with or without the expression of ALK^F1174L to determine the pathogenic consequences of the ALK^F1174L/MYCN interaction in neuroblastoma.

ORGANISM(S): Mus musculus

PROVIDER: GSE35560 | GEO | 2012/07/05

SECONDARY ACCESSION(S): PRJNA152681

REPOSITORIES: GEO

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