Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Macrophages and dendritic cells exposed to phylogenetically distinct parasites

ABSTRACT: Monocyte-derived dendritic cells (DC) and macrophages (MΦ) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger. Keywords: equivalent probe

ORGANISM(S): Homo sapiens

PROVIDER: GSE360 | GEO | 2003/03/26

SECONDARY ACCESSION(S): PRJNA84853

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of human macrophages and dendritic cells exposed to phylogenetically distinct parasites

Project description:Monocyte-derived dendritic cells (DC) and macrophages (MÎ¦) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger.<br><br>Note that the following pairs of files as imported from GEO are identical: GSM5135.txt and GSM5144.txt; GSM5137.txt and GSM5138.txt; GSM5143.txt and GSM5150.txt; GSM5148.txt and GSM5155.txt

2007-12-13 | E-GEOD-360 | biostudies-arrayexpress

Transcription profiling of Leismania donovani wild type and centrin-gene knock out cultured in conditions that induce failure of cell division

Project description:Study of gene expression differences between wild type and genetically modified Leishmania donovani protozoan parasites. A centrin-gene-deleted cell line after 40 hours in culture conditions that induce failure of cell division is compared to wild type cells under the same culture conditions.

2009-08-27 | E-MEXP-1825 | biostudies-arrayexpress

Drug repurposing of bromodomain inhibitors as potential novel therapeutic leads for lymphatic filariasis guided by multi-species transcriptomics

Project description:Brugia malayi, Wolbachia (wBm), and Aedes aegypti transcriptome reads from across the B. malayi FR3 life cycle

2019-11-20 | GSE139965 | GEO

Microarray analysis of Brugia malayi microfilariae-derived extracellular vesicles (Evs) and supernatants

Project description:We report our microarray analysis of Brugia malayi microfilariae-derived miRNA comparing parasite-derived EVs and supernatants Microarray analysis was performed using isolated RNA from three biological replicates of Brugia malayi microfilariae with a focus on the parasite-derived EVs and supernatant

2021-01-12 | GSE157226 | GEO

Differential gene transcript expression profiles among human monocyte-derived dendritic cells infected with Leishmania major Friedlin V1 strain and Leishmania donovani 1S strain parasites at early infection time points

Project description:Monocyte derived dendritic cells (MDDC) were infected with Leishmania major or Leishmania donovani parasites and collected at 4, 8, and 24 hours post-infection to analyze the differential effects those parasite species have on human host cell gene expression over time. Monocyte derived dendritic cells (MDDC) were generated from blood buffy coats collected from five anonymous healthy human donors and infected 10:1 (parasite to host cell) with Leishmania major Friedlin V1 strain or Leishmania donovani 1S strain parasites, where after 4, 8, or 24 hours total RNA was harvested from cells, cDNA generated, and hybridized to human gene transcipt expression arrays to assess differential host cell gene transcriptional expression differences relative to uninfected cells.

2015-01-02 | E-GEOD-64610 | biostudies-arrayexpress

2015-01-02 | GSE64610 | GEO

Effect of Doxycycline on Wolbachia and Brugia malayi adult female worms in vivo

Project description:Doxycycline treatment affects gene expression in Wolbachia and Brugia malayi adult female worms in vivo

2012-01-16 | GSE34976 | GEO

Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani.

2016-01-01 | GSE62468 | GEO

Profiling of gender based transcripts of Brugia malayi

Project description:Transcriptional profiling of adult males and females of the lymphatic dwelling filarial parasite Brugia malayi Keywords: Gender based transcripts, filaria

2010-12-30 | GSE12944 | GEO

Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani. The antimony resistant and sensitive Leishmania donovani were grown in complete M199 medium with 10% FCS and Penicillin streptomycin mixture. At stationary phase (5 day culture) cells were harvested in sterile Phosphate buffered saline and used for RNA isolation.

2016-07-03 | E-GEOD-62468 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data