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A genomic storm in critically injured humans

ABSTRACT: Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. Furthermore, complications like nosocomial infections and organ failure are not associated with any genomic evidence of a second hit and differ only in the magnitude and duration of this genomic reprioritization.

ORGANISM(S): Homo sapiens

PROVIDER: GSE36809 | GEO | 2012/03/27

SECONDARY ACCESSION(S): PRJNA156919

REPOSITORIES: GEO

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A genomic storm in critically injured humans

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