Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Clonal competition with alternating dominance in multiple myeloma [44kCGH]

ABSTRACT: Copy number and Gene expression profiling multiple myeloma patients at multiple stages of their individual clinical course Identification of evolutionary paterns in multiple myeloma

ORGANISM(S): Homo sapiens

PROVIDER: GSE36823 | GEO | 2012/03/28

SECONDARY ACCESSION(S): PRJNA157185

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Clonal competition with alternating dominance in multiple myeloma [244kCGH]

2012-03-28 | GSE36822 | GEO

Clonal competition with alternating dominance in multiple myeloma [244kCGH]

Project description:Copy number and Gene expression profiling multiple myeloma patients at multiple stages of their individual clinical course Identification of evolutionary paterns in multiple myeloma Copy number differences between individual CD138 purified tumor populations from multiple myeloma patients and control female using the Agilent 244A Human CGH microarray

2012-03-27 | E-GEOD-36822 | biostudies-arrayexpress

Clonal competition with alternating dominance in multiple myeloma [44kCGH]

2012-03-27 | E-GEOD-36823 | biostudies-arrayexpress

Clonal competition with alternating dominance in multiple myeloma [GEP]

2012-03-28 | GSE36824 | GEO

Clonal competition with alternating dominance in multiple myeloma [GEP]

Project description:Copy number and expression profiling of multiple myeloma patients at multiple stages of their individual clinical course Identification of evolutionary patterns in multiple myeloma Gene expression analysis of individual CD138 purified tumor populations using Affymertix U133Plus2.0 GeneChips

2012-03-27 | E-GEOD-36824 | biostudies-arrayexpress

Clonal competition with alternating dominance in multiple myeloma

Project description:This SuperSeries is composed of the following subset Series: GSE36822: Clonal competition with alternating dominance in multiple myeloma [244kCGH] GSE36823: Clonal competition with alternating dominance in multiple myeloma [44kCGH] GSE36824: Clonal competition with alternating dominance in multiple myeloma [GEP] Refer to individual Series

2012-03-27 | E-GEOD-36825 | biostudies-arrayexpress

Clonal competition with alternating dominance in multiple myeloma.

Project description:Emerging evidence indicates that tumors can follow several evolutionary paths over a patient's disease course. With the use of serial genomic analysis of samples collected at different points during the disease course of 28 patients with multiple myeloma, we found that the genomes of standard-risk patients show few changes over time, whereas those of cytogenetically high-risk patients show significantly more changes over time. The results indicate the existence of 3 temporal tumor types, which can either be genetically stable, linearly evolving, or heterogeneous clonal mixtures with shifting predominant clones. A detailed analysis of one high-risk patient sampled at 7 time points over the entire disease course identified 2 competing subclones that alternate in a back and forth manner for dominance with therapy until one clone underwent a dramatic linear evolution. With the use of the Vk*MYC genetically engineered mouse model of myeloma we modeled this competition between subclones for predominance occurring spontaneously and with therapeutic selection.

| S-EPMC3412330 | biostudies-literature

Clonal competition with alternating dominance in multiple myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-03-28 | GSE36825 | GEO

Multiple myeloma

Project description:Multiple myeloma

| PRJNA515992 | ENA

Multiple Myeloma cells

Project description:Multiple Myeloma cells

| PRJNA800411 | ENA