HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages
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ABSTRACT: In the immune system HDAC7 is expressed in T cells where it regulates the expression of key genes for T cell development and function. Here we report that HDAC7 is also highly expressed in B cell precursors, where it is recruited by MEF2C to repress the activity of key genes for myeloid cell function. While HDAC7 is down-regulated during the conversion of pre-B cells into macrophages, re-expression of HDAC7 interferes with both the acquisition of the myeloid gene transcriptional program and macrophage specific cell functions. Thus, HDAC7 is a novel transcriptional repressor of lineage inappropriate genes in B cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE36827 | GEO | 2014/03/25
SECONDARY ACCESSION(S): PRJNA156927
REPOSITORIES: GEO
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