Genomics

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Spreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations


ABSTRACT: Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichment of SINEs and simple repeats. The general pattern of Ezh2 and H3K27me3 distribution over the chromosome reflect a graded concentration originating from strong Ezh2 sites, around which moderate sites are clustered, suggesting a hierarchy of Ezh2 sites govern spreading.

ORGANISM(S): Mus musculus

PROVIDER: GSE36905 | GEO | 2012/11/01

SECONDARY ACCESSION(S): PRJNA157029

REPOSITORIES: GEO

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