Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fz2-Fz7 double knock-out E8.5 mouse

ABSTRACT: Fz2Fz7 double knock out mouse microarray (E8.5)

ORGANISM(S): Mus musculus

PROVIDER: GSE37221 | GEO | 2012/04/13

SECONDARY ACCESSION(S): PRJNA159175

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Fz2-Fz7 double knock-out E8.5 mouse

Project description:Fz2Fz7 double knock out mouse microarray (E8.5) Fz2-Fz7 double KO vs. Fz7 KO

2012-04-12 | E-GEOD-37221 | biostudies-arrayexpress

Microarray of wild type, Shp2 knock-out, Pten knock-out and double knock-out erythroblasts

Project description:the gene expression profiling results provide important information for the genes regulated by crosstalk between Shp2 and Pten mediated signal pathways Total RNA was extracted from CD71mid Ter119high erythroblasts isolated from the bone marrow of wide type, Shp2 knock-out, Pten knock-out and double knock-out mice

2013-07-03 | E-GEOD-48477 | biostudies-arrayexpress

Transcriptome of single and double pannexin1-knock out zebrafish lines

Project description:Transcriptome of single and double pannexin1-knock out zebrafish lines

| PRJNA753704 | ENA

Mus musculus

Project description:Fz2-Fz7 double knock-out E8.5 mouse

| PRJNA159175 | ENA

ARRDC4 knock out Mouse Heart Analysis

Project description:ARRDC4 knock out Mouse Heart Analysis

| PRJNA773414 | ENA

Transcription profiling of heart from wild type and Murf1/2 double knock out mice

Project description:Comparison of the transcriptome of Wildtype versus Murf1/2 double Knock Out (dKO) mouse hearts is analyzed

2008-01-15 | E-MEXP-1321 | biostudies-arrayexpress

Exacerbated neuronal ceroid lipofuscinosos phenotype in Cln1/5 double knock-out mice

Project description:Both CLN1 and CLN5 deficiency leads to severe neurodegenerative diseases of childhood, known as neuronal ceroid lipofuscinoses (NCL). The broadly similar phenotypes of NCL mouse models, and the potential for interactions between NCL proteins, raise the possibility of shared or converging disease mechanisms. To begin addressing these issues we have developed a novel mouse model lacking both Cln1 and Cln5 genes. These Cln1/5 double knock-out (Cln1/5 dko) mice were fertile, showing a slight decrease in expected Mendelian breeding ratios, as well as impaired embryoid body formation of induced pluripotent stem cells derived from Cln1/5 dko fibroblasts. Typical manifestations of the NCL diseases, seizures and motor dysfunction, were detected at the age of 3 months, earlier than in either single knock-out mouse. Pathological analyses revealed a similar exacerbation and earlier onset of disease in Cln1/5 dko mice, which exhibit a pronounced accumulation of autofluorescent storage material. Cortical demyelination and more pronounced glial activation in cortical and thalamic regions was followed by cortical neuron loss. Alterations in lipid metabolism in Cln1/5 dko showed specifically an increase in serum phospholipid transfer protein (PLTP) activity. Finally, gene expression profiling of Cln1/5 dko cortex revealed defects in myelination and immune response pathways, with a prominent downregulation of alpha-synuclein in Cln1/5 dko mouse brains. The simultaneous loss of both Cln1 and Cln5 genes may enhance the typical pathological phenotypes of these mice by disrupting down shared or convergent pathogenic pathways, which may potentially include interactions of CLN1 and CLN5. Basic characterization of Cln1/5 double knock-out mouse model. Aim was to find possible differentially expressed genes and up-or downregulated pathways in Cln1/5 double knock-out vs. wild-type mouse cortex. Total RNA isolated from 1 month old Cln1-/-/Cln5-/- mouse cortex.

2012-10-31 | E-GEOD-37643 | biostudies-arrayexpress

Transcription profiling of Arabidopsis wild type Col-0 and hsf407 double knock out plants after heat stress

Project description:Effect of heat stress on wildtype COL-0 Arabidopsis and hsf4-7 double knock out plants.

2008-12-31 | E-MEXP-1725 | biostudies-arrayexpress

Mouse HFD Liver Skeletal Muscle SLC16A13 Knock-Out

Project description:Mouse HFD Liver Skeletal Muscle SLC16A13 Knock-Out

| PRJNA641022 | ENA

anaerobic knock-out

Project description:Six different knock-out strains' expression data under anaerobic condition Keywords: parallel sample

2004-03-10 | GSE1107 | GEO